Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment

Gasparotto, Juciano; Saibro Girardi, Carolina; Somensi, Nauana; Tiefensee Ribeiro, Camila; Cláudio Fonseca Moreira, José; Michels, Monique; Sonai, Beatriz; Rocha, Mariane; V. Steckert, Amanda; Barichello, Tatiana; Quevedo, JoΔo; Dal‐Pizzol, Felipe; Pens Gelain, Daniel

doi:10.1074/jbc.m117.786756

Public

Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment

Published in Journal of Biological Chemistry • Nov 10, 2017

Authors:

Juciano Gasparotto

Carolina Saibro Girardi

Nauana Somensi

Abstract

accumulation, Akt/mechanistic target of rapamycin signaling, levels of ionized calcium-binding adapter molecule 1 and glial fibrillary acidic protein, and behavioral deficits associated with cognitive decline. These results indicate that brain RAGE is an essential factor in the pathogenesis of neuro...

Subject

Rage (emotion)

Glycation

Proinflammatory cytokine

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