Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia

Peng, Fei; Wang, J-H; Fan, W-J; Meng, Y-T; Li, M-M; Li, T-T; Cui, Bai; F. Wang, H.; D. Zhao, Yidan; An, Fengmin; Guo, Ting; Liu, X-F; Zhang, Lei; Lv, Li; Lv, D-K; Xu, L-Z; Xie, J-J; Lin, W-X; W.‐F. Lam, Eric; Xu, Jiao; Liu, Qiang

doi:10.1038/onc.2017.368

Public

Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia

Published in Oncogene • Nov 6, 2017

Authors:

Fei Peng

J-H Wang

W-J Fan

Abstract

Abstract Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH + subpopul...

Subject

Biology

Reprogramming

Cancer research

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