DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways

Jin, Qinhua; Li, Ruibing; Hu, Nan; Xin, Ting; Zhu, Pingjun; Hu, Shunying; Ma, Sai; Zhu, Hong; Ren, Jun; Zhou, Hao

doi:10.1016/j.redox.2017.11.004

Public

DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways

Published in Redox Biology • Nov 6, 2017

Authors:

Qinhua Jin

Ruibing Li

Nan Hu

Abstract

Mitochondrial fission and selective mitochondrial autophagy (mitophagy) form an essential axis of mitochondrial quality control that plays a critical role in the development of cardiac ischemia-reperfusion (IR) injury. However, the precise upstream molecular mechanism of fission/mitophagy remains un...

Subject

Mitophagy

Mitochondrial fission

Cell biology

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