HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

Du, Weinan; Zhang, Luchang; Brett-Morris, Adina; Aguila, Brittany; Kerner, János; L. Hoppel, Charles; Puchowicz, Michelle; Serra, Dolors; Herrero, Laura; I. Rini, Brian; C. Campbell, Steven; M. Welford, Scott

doi:10.1038/s41467-017-01965-8

Public

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

Published in Nature Communications • Nov 20, 2017

Authors:

Weinan Du

Luchang Zhang

Adina Brett-Morris

Abstract

Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-rich cytoplasmic deposits. Alterations in the VHL tumor suppressor stabilizing the hypoxia-inducible factors (HIFs) are the most prevalent molecular features of clear cell tumors. The significance of lipid de...

Subject

Lipid metabolism

Beta oxidation

Carnitine

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