Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells.

Welby, Emily; Lakowski, Jorn; Di Foggia, Valentina; Budinger, Dimitri; Gonzalez-Cordero, Anai; T L Lun, Aaron; Epstein, Michael; Patel, Aara; Cuevas, Elisa; Kruczek, Kamil; Naeem, Arifa; Minneci, Federico; Hubank, Mike; T Jones, David; C Marioni, John; R Ali, Robin; C Sowden, Jane

doi:10.1016/j.stemcr.2017.10.018

Public

Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells.

Shared by NobleBlocks on Dec 12, 2017 • 12:00 AM UTC

Authors:

Emily Welby

Jorn Lakowski

Valentina Di Foggia

Abstract

Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in retinal degeneration. Transplantation of stem cell-derived L/M-opsin cones, which form 90% of the human cone population, could provide a feasible therapy to restore vision. However, transcriptomic similarit...

Subject

cell surface markers

cell transplantation therapy

cone photoreceptor cells

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