Structures of PPARγ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs

A Lee, Min; Tan, Lingchen; Yang, Huiseon; Im, Yeong-Gwan; Jun Im, Young; Jun Im, Young; Jun Im, Young

doi:10.1038/s41598-017-17082-x

Public

Structures of PPARγ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs

Published in Scientific Reports • Nov 28, 2017

Authors:

Min A Lee

Lingchen Tan

Huiseon Yang

Abstract

Peroxisome proliferator-activator receptor (PPAR) γ is a nuclear hormone receptor that regulates glucose homeostasis, lipid metabolism, and adipocyte function. PPARγ is a target for thiazolidinedione (TZD) class of drugs which are widely used for the treatment of type 2 diabetes. Recently, lobeglita...

Subject

Pioglitazone

Rosiglitazone

Thiazolidinedione

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