Long Noncoding RNA NEAT1 , Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/ β -Catenin Pathway by Scaffolding EZH2

Chen, Qun; Cai, Jinquan; Wang, Qixue; Wang, Yunfei; Liu, Mingyang; Yang, Jingxuan; Zhou, Junhu; Kang, Chunsheng; Min, Li; Jiang, Chuanlu

doi:10.1158/1078-0432.ccr-17-0605

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Long Noncoding RNA NEAT1 , Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/ β -Catenin Pathway by Scaffolding EZH2

Published in Clinical Cancer Research • Nov 14, 2017

Authors:

Qun Chen

Jinquan Cai

Qixue Wang

Abstract

Abstract Purpose: Long noncoding RNAs have been implicated in gliomagenesis, but their mechanisms of action are mainly undocumented. Through public glioma mRNA expression data sets, we found that NEAT1 was a potential oncogene. We systematically analyzed the clinical significance and mechanism of NE...

Subject

Long non-coding RNA

Glioblastoma

Wnt signaling pathway

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