Molecular and cellular reorganization of neural circuits in the human lineage

M. M. Sousa, André; Zhu, Ying; Ann Raghanti, Mary; R. Kitchen, Robert; Onorati, Marco; T.N. Tebbenkamp, Andrew; Stutz, Bernardo; A. Meyer, Kyle; Li, Mingfeng; Imamura Kawasawa, Yuka; Liu, Fuchen; García-Pérez, Raquel; Melé, Marta; Carvalho, Tiago; Škarica, Mario; O. Gulden, Forrest; Pletikos, Mihovil; Shibata, Akemi; R. Stephenson, Alexa; K. Edler, Melissa; J. Ely, John; D. Elsworth, John; L. Horváth, Tamás; R. Hof, Patrick; M. Hyde, Thomas; E. Kleinman, Joel; R. Weinberger, Daniel; Reimers, Mark; P. Lifton, Richard; Mane, Shrikant; P. Noonan, James; W. State, Matthew; S. Lein, Ed; A. Knowles, James; Marquès‐Bonet, Tomàs; C. Sherwood, Chet; Gerstein, Mark; Šestan, Nenad

doi:10.1126/science.aan3456

Public

Molecular and cellular reorganization of neural circuits in the human lineage

Published in Science • Nov 23, 2017

Authors:

André M. M. Sousa

Ying Zhu

Mary Ann Raghanti

Abstract

To better understand the molecular and cellular differences in brain organization between human and nonhuman primates, we performed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains. Integration with human single-cell transcriptomic data revealed global, regional,...

Subject

Neocortex

Neuroscience

Primate

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