Genotype-Specific Minimal Residual Disease Interpretation Improves Stratification in Pediatric Acute Lymphoblastic Leukemia

O’Connor, David; Enshaei, Amir; Bartram, Jack; Hancock, Jeremy; J. Harrison, Christine; Hough, Rachael; Samarasinghe, Sujith; Schwab, Claire; Vora, Ajay; Wade, Rachel; Moppett, John; V. Moorman, Anthony; Goulden, Nick

doi:10.1200/jco.2017.74.0449

Public

Genotype-Specific Minimal Residual Disease Interpretation Improves Stratification in Pediatric Acute Lymphoblastic Leukemia

Published in Journal of Clinical Oncology • Nov 13, 2017

Authors:

David O’Connor

Amir Enshaei

Jack Bartram

Abstract

Purpose Minimal residual disease (MRD) and genetic abnormalities are important risk factors for outcome in acute lymphoblastic leukemia. Current risk algorithms dichotomize MRD data and do not assimilate genetics when assigning MRD risk, which reduces predictive accuracy. The aim of our study was to...

Subject

Minimal residual disease

Medicine

Oncology

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