Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

Solimena, Michele; M. Schulte, Anke; Marselli, Lorella; Ehehalt, Florian; Richter, Daniela; Kleeberg, Manuela; Mziaut, Hassan; Knoch, Klaus-Peter; Parnis, Julia; Bugliani, Marco; Siddiq, Afshan; Jörns, Anne; Burdet, Frédéric; Liechti, Robin; Suleiman, Mara; Margerie, Daniel; Syed, Farooq; Distler, Marius; Grützmann, Robert; Petretto, Enrico; Moreno‐Moral, Aida; Wegbrod, Carolin; Sönmez, Anke; Pfriem, Katja; Friedrich, Anne; Meinel, Jörn; B. Wollheim, Claes; Baretton, Gustavo; Scharfmann, Raphaël; Nogoceke, Everson; Bonifacio, Ezio; Sturm, Dorothée; Meyer‐Puttlitz, Birgit; Boggi, Ugo; Saeger, Hans‐Detlev; Filipponi, Franco; Lesche, Mathias; Meda, Paolo; Dahl, Andreas; Wigger, Leonore; Xénarios, Ioannis; Falchi, Mario; Thorens, Bernard; Weitz, Jürgen; Bokvist, Krister; Lenzen, Sigurd; A. Rutter, Guy; Froguel, Philippe; von Bülow, Manon; Ibberson, Mark; Marchetti, Piero

doi:10.1007/s00125-017-4500-3

Public

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

Published in Diabetologia • Nov 28, 2017

Authors:

Michele Solimena

Anke M. Schulte

Lorella Marselli

Abstract

AIMS/HYPOTHESIS: Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in D...

Subject

Type 2 diabetes

Diabetes mellitus

Transcriptome

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!