MicroRNA-133 overexpression promotes the therapeutic efficacy of mesenchymal stem cells on acute myocardial infarction

Chen, Yueqiu; Zhao, Yunfeng; Chen, Weiqian; Xie, Lincen; Zhao, Zhen‐Ao; Yang, Junjie; Chen, Yihuan; Lei, Wei; Shen, Zhenya

doi:10.1186/s13287-017-0722-z

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MicroRNA-133 overexpression promotes the therapeutic efficacy of mesenchymal stem cells on acute myocardial infarction

Published in Stem Cell Research & Therapy • Nov 24, 2017

Authors:

Yueqiu Chen

Yunfeng Zhao

Weiqian Chen

Abstract

BACKGROUND: Our study aim was to evaluate the therapeutic efficacy and mechanisms of miR-133-overexpressing mesenchymal stem cells (MSCs) on acute myocardial infarction. METHODS: Rat MSCs were isolated and purified by whole bone marrow adherent culturing. After transfection with the agomir or antago...

Subject

Mesenchymal stem cell

Stem cell

Myocardial infarction

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