Zinc-finger proteins in health and disease

Cassandri, Matteo; Smirnov, Artem; Novelli, Flavia; Pitolli, Consuelo; Agostini, Massimiliano; Malewicz, Michal; Melino, Gerry; Raschellà, Giuseppe

doi:10.1038/cddiscovery.2017.71

Public

Zinc-finger proteins in health and disease

Published in Cell Death Discovery • Nov 13, 2017

Authors:

Matteo Cassandri

Artem Smirnov

Flavia Novelli

Abstract

Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are able to interact with DNA, RNA, PAR (poly-ADP-ribose) and other proteins. Thus, ZNFs are involved in the regulation of sev...

Subject

Zinc finger

Zinc

Zinc finger nuclease

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