The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

Boyé, Kevin; Pujol, Nadège; D. Alves, Isabel; Chen, Yaping; Daubon, Thomas; Lee, Yi-Zong; Dedieu, Stéphane; Constantin, Marion; Bello, Lorenzo; Rossi, Marco; Bjerkvig, Rolf; Sue, Shih‐Che; Bikfalvi, Andréas; Billottet, Clotilde

doi:10.1038/s41467-017-01686-y

Public

The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

Published in Nature Communications • Nov 13, 2017

Authors:

Kevin Boyé

Nadège Pujol

Isabel D. Alves

Abstract

CXCR3 plays important roles in angiogenesis, inflammation, and cancer. However, the precise mechanism of regulation and activity in tumors is not well known. We focused on CXCR3-A conformation and on the mechanisms controlling its activity and trafficking and investigated the role of CXCR3/LRP1 cros...

Subject

LRP1

CXCR3

Cell biology

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