The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

Boyé, Kevin; Pujol, Nadège; D Alves, Isabel; Chen, Ya-Ping; Daubon, Thomas; Lee, Yi-Zong; Dedieu, Stephane; Constantin, Marion; Bello, Lorenzo; Rossi, Marco; Bjerkvig, Rolf; Sue, Shih-Che; Bikfalvi, Andreas; Billottet, Clotilde

doi:10.1038/s41467-017-01686-y

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The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

Shared by NobleBlocks on Nov 17, 2017 • 12:00 AM UTC

Authors:

Kevin Boyé

Nadège Pujol

Isabel D Alves

Abstract

Abstract CXCR3 plays important roles in angiogenesis, inflammation, and cancer. However, the precise mechanism of regulation and activity in tumors is not well known. We focused on CXCR3-A conformation and on the mechanisms controlling its activity and trafficking and investigated the role of CXCR3/...

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