Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study

E. Dorman, Susan; G. Schumacher, Samuel; Alland, David; Nabeta, Pamela; T. Armstrong, Derek; King, Bonnie; L. Hall, Sandra; Chakravorty, Soumitesh; María Cirillo, Daniela; Tukvadze, Nestani; Bablishvili, Nino; Stevens, Wendy; Scott, Lesley; Rodrigues, Camilla; Kazi, Mubin; Joloba, Moses; Nakiyingi, Lydia; P. Nicol, Mark; Ghebrekristos, Yonas; Anyango, Irene; Murithi, Wilfred; Dietze, Reynaldo; Lyrio Peres, Renata; Skrahina, Alena; Auchynka, Vera; Kishore Chopra, Kamal; Hanif, Mahmud; Liu, Xin; Yuan, Xing; Boehme, Catharina; J. Ellner, Jerrold; M. Denkinger, Claudia; E. Dorman, Susan; G. Schumacher, Samuel; Alland, David; Nabeta, Pamela; T. Armstrong, Derek; King, Bonnie; L. Hall, Sandra; Chakravorty, Soumitesh; María Cirillo, Daniela; Tukvadze, Nestani; Bablishvili, Nino; Stevens, Wendy; Scott, Lesley; Rodrigues, Camilla; Kazi, Mubin; Joloba, Moses; Nakiyingi, Lydia; P. Nicol, Mark; Ghebrekristos, Yonas; Anyango, Irene; Murithi, Wilfred; Dietze, Reynaldo; Lyrio Peres, Renata; Skrahina, Alena; Auchynka, Vera; Kishore Chopra, Kamal; Hanif, Mahmud; Liu, Xin; Yuan, Xing; Boehme, Catharina; J. Ellner, Jerrold; M. Denkinger, Claudia; C. Manabe, Yukari; L. Hom, David; Aspindzelashvili, Rusudan; David, Anura; Surve, Utkarsha; Henry Kamulegeya, Louis; Nabweyambo, Sheila; Surtie, Shireen; Hapeela, Nchimunya; P. Cain, Kevin; Agaya, Janet; D. McCarthy, Kimberly; Marques-Rodrigues, Patrícia; Guilherme Schmidt Castellani, Luiz; Sousa de Almeida Júnior, Pedro; Poloni Lobo de Aguiar, Paola; Solodovnikova, Varvara; Ruan, Xianglin; Liang, Lili; Zhang, Guolong; Zhu, Hong; L. Xie, Yingda

doi:10.1016/s1473-3099(17)30691-6

Public

Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study

Published in The Lancet Infectious Diseases • Nov 30, 2017

Authors:

Susan E. Dorman

Samuel G. Schumacher

David Alland

Abstract

BACKGROUND: The Xpert MTB/RIF assay is an automated molecular test that has improved the detection of tuberculosis and rifampicin resistance, but its sensitivity is inadequate in patients with paucibacillary disease or HIV. Xpert MTB/RIF Ultra (Xpert Ultra) was developed to overcome this limitation....

Subject

Medicine

Tuberculosis

Sputum

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