Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial

Thwaites, Guy; Scarborough, Matthew; J. Szubert, Alexander; Nsutebu, Emmanuel; Tilley, Robert; Greig, Julia; Wyllie, Sarah; Wilson, Peter; Auckland, Cressida; Cairns, Janet; Ward, Denise; Lal, Pankaj; Guleri, Achyut; Jenkins, Neil; Sutton, Julian; Wiselka, Martin; González-Ruiz, Armando; Graham, Clive; Chadwick, Paul; Barlow, Gavin; Claire Gordon, N; Young, Bernadette; Meisner, Sarah; McWhinney, Paul; Price, David; Harvey, David; Nayar, Deepa; Jeyaratnam, Dakshika; Planche, Tim; Minton, Jane; Hudson, Fleur; Hopkins, Susan; Williams, John; Estée Török, M.; Llewelyn, Martin; D. Edgeworth, Jonathan; Sarah Walker, A; Scarborough, Matthew; Kamfose, Musa; de Veciana, Ana; Claire Gordon, N; Peto, Leon; Pill, Gemma; Clarke, Tiphanie; Watson, Laura; Young, Bernadette; Ll. Griffiths, D.; N. Vaughn, A.; Anson, Luke; Liu, Elian; Perera, Sanuki; Rylance-Knight, Lydia; Cantell, Carmen; Moroney, Ruth; D. Edgeworth, Jonathan; Thwaites, Guy; Bisnauthsing, Karen; Querol-Rubiera, Antonio; Gibbs, Charlotte; Patel, Amita; Hemsley, Carolyn; L. Goodman, Anna; Wyncoll, Duncan; Biswas, Jason; M. Fitzpatrick, Jennifer; Jackson Roberts, L.; Millard, James; E. Stone, N.; Cape, Angela; Hurley, Lisa; Kai Tam, Chi; Nsutebu, Emmanuel; Hoyle, Marie-Claire; Maitland, Kate; Trainor, Leona; Reynolds, Helen; Harrison, Jennifer; Anson, Jim; M. Lewis, Joseph; Folb, Jonathan; Goodwin, Lynsey; J. Beeching, Nicholas; Dyas, Sarah; Winslow, Helen; A. Foote, Elizabeth; C. Roberts, Paul; Natarajan, Pavithra; Chrdle, Alex; Fenech, Manuel; Allsop, Hannah; Tilley, Robert; Austin-Hutchison, Rachel; Barrett, Louise; Brookes, Karen; Carwithen, Leanne; Conbeer, Andrew; Cunningham, Richard; Eglinton, Charlotte; Fok, Rosie; Gott, Hannah; Hughes, S; Jones, Lewis; Kalita, Maggie; G. King, Angela; March, Linda; Marner, Mike; Mynes, Tracey; Plant, Aiden; Price, Suzanne; Sercombe, J.; Stolton, Alison; Wallis, Mark; West, Marie-Claire; Westcott, Jackie; Williams, Claire; Wosley, Rob; Yabsley, Leona; Greig, Julia; Butland, Laura; Sorrell, Julie; Mitchell, Tamara; Alli, Abiola; Meiring, James; Masake, Boingotlo; Rowson, Carlene; Smart, L.I.; Makey, Laura; Moll, Sarah; Cunningham, Jane; Ryalls, Kim; Birchall, Kathryn; Middle, Janet; Jackson, Yvonne; Swift, Diane; Cole, Joby; Subramanian, Bala; Okhuoya, Faith; Edwards, Maria; H. Bailey, C.; Warren, Rebecca; Islam, Gayti; Ankcorn, Michael; Birchall, Sarah; D. Jones, Paul; Eric Humphries, John; Booth, Stephen; Evan, Cariad; Wyllie, Sarah; Flatt, A.; Straková, Lenka; F. Hayes, Maria; L. Valentine, Stacey; James, Clare; Wands, Mary; Cortes, Nicolas; Khan, Nisa; Porter, Robert; Martin, Zoe; Yip, Keith; Preedy, Helen; Chesterfield, Helen; Dobson, Tracey; Walker, Colin; Llewelyn, Martin; Dunne, Angela; Latter, Laura; Porges, Alison; Price, James; R. Paul, John; Behar, Laura; Robinson, Louise; Murray, Amy; M. Fitzpatrick, Jennifer; Sargent, T.W.; Ridley, Carrie; Ortiz-Ruiz de Gordoa, Laura; Gilliam, D.R.; McPherson, Carole; Matthews, Simon; Foreman, Emma; Jarghese, Rajesh; Beddoe, Alisha; Martin, Sébastien; Shaw, Sephora; Wlazly, Dominika; Cole, Maggie; Gihawi, Abraham; Cole, Kevin; Estée Török, M.; Gouliouris, Theodore; Bedford, Luke; B. Saunderson, Rebecca; Mariolis, Ilias; Bousfield, Rachel; Ramsay, Isobel; Greaves, Daniel; H. Aliyu, Sani; Cox, Kim; Mlemba, Lois; Whitehead, Lynne; Vyse, Naval; Bolton, Mark; Williams, John; Lambert, Pauline; Chadwick, David; Baillie, Kirsty; Cain, Martyn; Bellamy, Richard; W.H. Wong, Jason; Thompson, Jane; Vassallo, Helen; Skotnicka, Agnieszka; Boyce, Andrea; Donnelly, Anthony; Wilson, Peter; FitzGerald, Graham; Dean, Victoria; Warnes, Kristian; Reyes, Anna; Rahman, Saadia; Tsang, L.-C.; Williams, Joanne; Morris‐Jones, Stephen; Hopkins, Susan; Witness, Elen; Brady, O.; Woodford, Elizabeth; Pettifer, Teresa; McCadden, Angela; Marks, Ben; Collier, Sophie; Mack, Damien; Warren, Simon; Brown, Colin; Lyons, Adrian; Taiyari, Sara; Mepham, Stephen; Sweeney, Anna; K. Brown, Li‐An; Auckland, Cressida; J. Potter, Alison; Mandiza, Jess; Hough, Maxine; Williams, Sue; Renton, Caroline; Walters, Fiona; Nadolski, Maria; Evans, Andree; Tarrant, P.V.; Curley, Katherine; Whiteley, Sophie; Halpin, Julia; Hutchings, Melanie; Todd, Shirley; Lohan, C.; Chapter, Tamika; Folland, Emma; Colville, Alaric; Marden, Katy; Morgan, Marina; Fok, Rosie; Porter, Rob; Baxter, Mel; Minton, Jane; Rippon, Sarah; Çevik, Müge; Chapman, Judith; Kemp, T; Vincent, Rachel; Osborne, Dave; Platt, Tracey; Calderwood, James; Cook, Bernadette; Bedford, Caroline; Galloway-Browne, Leanne; Abberley, Nadine; Attack, Kelly; Allen, Joanna; Lal, Pankaj; Harrison, Melanie; Stevenson, Sarah; Brooks, Carol; Harlow, Paula; Ewing, Jordan; Cooper, Shirley; Balancio-Tolentino, Roderick; O’Neil, Laura; Tagney, Rebecca; Shackcloth, Daniela; Planche, Tim; L. Fellows, James; Millett, Ruth; M. STUDHAM, J.; de Souza, Cherrelle; Howell, Geoffrey; Greaves, Hezron; Foncel, Ella; Kurup, R.; Nixon Briggs, J.; Smith, Melody; Suárez, Cristina; Sorrentino, Giordana; Scobie, Antonia; Houston, Angela; Ahmad, Fozia; S. Breathnach, Aodhán; Chahuan, Rakhee; Wilkins, Katie; Guleri, Achyut; Waddington, Natalia; Sharma, Rashmi; J Flegg, P; Kollipara, Veenu; Alam, Mazhar; Potter, Andrew; Donaldson, Stacey; Armer, Charlote; Frudd, Julie; Jeyaratnam, Dakshika; Joy, Manju; Mathews, Asha; Glass, Stephen; Ajayi, Ayodele; Fife, Amanda; Qaiser, Saba; R. Sheehan, Sharon; Muñoz-Villaverde, Sergio; Yogo, Noah; De Abreu, Ines; Notcheva, Gaynor; Flanagan, Joanna; Watson, Cordelia; Sais, Efisia; Adedayo, Adetunji; Chu, Vicky; Shaw, Georgina; Angela Graver, Michelle; Palmer, Rebecca; M. Palmer, Donna; Haile, Senait; Gordon, Joanne; Kai Tam, Chi; Mandar, Kirandip; Szypura, Weronika; Jenkins, Neil; Marange, Josephine; Shabangu, Vusumuzi; H. P. 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Reed, Robert; Yam, T.; Burton, Holly; Said, Rasha; Harvey, David; Janvier, Amy; Jacob, Reni; Smalley, Chris; Fair, Alison; Lord, Susan; Ripalda, Kate; Wooldridge, Helen; Cotter, Luis; Cardoso, Gus; Strachan, Elaine; Kaler, Gagan; Mohamoodally, Adam; Lawrence, Emma; Prime, Zoe; Abrahams, Rachel; Price, David; Rigden, Lesley; Shewan, Laura; Cullen, Katherine; Emmerson, Ingrid; Martin, Karen; Wilson, Hesther; Higham, Charley; Louise Taylor, Kathryn; Ong, Edmund; Patel, Bijal; Bond, Helena; Gradwell, Janine; Widdrington, John; Graham, Clive; Thornthwaite, Sarah; Prentice, Scott; Poultney, Una; Crowther, Hannah; Fairlamb, Helen; Hetherington, Emily; Brewer, Chris; Banerjee, Suryabrata; Hamson, Clare; McSkeane, Anna; McWhinney, Paul; Sharratt, Paula; Thorpe, Joanne; Kimachia, Sue; Wilson, Helen; Jeffs, Benjamin; Masters, Leslie; M. Wilson, Jonathan; Platt, Judith; A. Burgess, Lisa; Chadwick, Paul; R. Jeans, Adam; Keatley, Claire; Moran, Amanda; Swann, Zoe; Pagett, Katherine; Peel, Alex; Howard, Jason; Meisner, Sarah; Nichole Maloney, K.; Masdin, Avril; Wright, Louise; Barlow, Gavin; Crossman, Samantha; Lowthorpe, Vicki; Moore, Emma; Moss, Peter; Parkin, Angela; Wolstencroft, Adam; Warner, Bev; Tarbotton, Clare; Eyre, Alison; Paige Anderson, A.; Burdett, Tina; Driffill, Amy; Sarah Walker, A.; Hudson, Fleur; J. Szubert, Alex; Cairns, Janet; Ward, Denise; Webb, Helen; Russell, Charlotte; Jackson, Brooke; Otiko, Damilola; Borg, Chiara; Masters, Lindsey; Islam, Zaheer; Díaz-Montaña, Carlos; Johnson, Debbie

doi:10.1016/s0140-6736(17)32456-x

Public

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial

Published in The Lancet • Dec 14, 2017

Authors:

Guy Thwaites

Matthew Scarborough

Alexander J. Szubert

Abstract

BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S...

Subject

Medicine

Placebo

Rifampicin

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