Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases

M. C. Connolly, Niamh; Theurey, Pierre; Ádám‐Vizi, Vera; G. Bazán, Nicolás; Bernardi, Paolo; P. Bolaños, Juan; Culmsee, Carsten; L. Dawson, Valina; Deshmukh, Mohanish; R. Duchen, Michael; Düßmann, Heiko; Fiskum, Gary; F. Galindo, Marı́a; E. Hardingham, Giles; Marie Hardwick, J.; B. Jekabsons, Mika; A. Jonas, Elizabeth; Jordán, Joaquı́n; A. Lipton, Stuart; Manfredi, Giovanni; P. Mattson, Mark; McLaughlin, BethAnn; Methner, Axel; N. Murphy, Anne; P. Murphy, Michael; G. Nicholls, David; M. Polster, Brian; Pozzan, Tullio; Rizzuto, Rosario; Satrústegui, Jorgina; S. Slack, Ruth; A. Swanson, Raymond; H. Swerdlow, Russell; Will, Yvonne; Ying, Zheng; Joselin, Alvin; Gioran, Anna; Moreira Pinho, Catarina; Watters, Orla; Salvucci, Manuela; Llorente‐Folch, Irene; S. Park, David; Bano, Daniele; Ankarcrona, Maria; Pizzo, Paola; H.M. Prehn, Jochen

doi:10.1038/s41418-017-0020-4

Public

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases

Published in Cell Death and Differentiation • Dec 11, 2017

Authors:

Niamh M. C. Connolly

Pierre Theurey

Vera Ádám‐Vizi

Abstract

Neurodegenerative diseases are a spectrum of chronic, debilitating disorders characterised by the progressive degeneration and death of neurons. Mitochondrial dysfunction has been implicated in most neurodegenerative diseases, but in many instances it is unclear whether such dysfunction is a cause o...

Subject

Neuroscience

Bioenergetics

Mitochondrion

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