Host DNases prevent vascular occlusion by neutrophil extracellular traps

Jiménez-Alcázar, Miguel; Rangaswamy, Chandini; Panda, Rachita; Bitterling, Josephine; J. Simsek, Yashin; T. Long, Andy; Bilyy, Rostyslav; Krenn, Veit; Renné, Christoph; Renné, Thomas; Kluge, Stefan; Panzer, Ulf; Mizuta, Ryushin; Georg Mannherz, Hans; Kitamura, Daisuke; Herrmann, Martin; Napirei, Markus; A. Fuchs, Tobias

doi:10.1126/science.aam8897

Public

Host DNases prevent vascular occlusion by neutrophil extracellular traps

Shared by NobleBlocks on Dec 1, 2017 • 12:00 AM UTC

Authors:

Miguel Jiménez-Alcázar

Chandini Rangaswamy

Rachita Panda

Abstract

Blood DNases hack the NET Neutrophil extracellular traps (NETs) are lattices of processed chromatin decorated with select secreted and cytoplasmic proteins that trap and neutralize microbes. However, their inappropriate release may do more harm than good by promoting inflammation and thrombosis. Jim...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!