ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes

Drago, Francesco; Lombardi, Marta; Prada, Ilaria; Gabrielli, Martina; Joshi, Pooja; Cojoc, Dan; Franck, Julien; Fournier, Isabelle; Vizioli, Jacopo; Verderio, Claudia

doi:10.3389/fphar.2017.00910

Public

ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes

Published in Frontiers in Pharmacology • Dec 13, 2017

Authors:

Francesco Drago

Marta Lombardi

Ilaria Prada

Abstract

Extracellular ATP is among molecules promoting microglia activation and inducing the release of extracellular vesicles (EVs), which are potent mediators of intercellular communication between microglia and the microenvironment. We previously showed that EVs produced under ATP stimulation (ATP-EVs) p...

Subject

Microglia

Cell biology

Extracellular

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