Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

B. Vogel, Annette; Lambert, Laura; Kinnear, Ekaterina; C. Busse, David; Erbar, Stephanie; C. Reuter, Kerstin; Wicke, Lena; Perković, Mario; Beißert, Tim; Haas, Heinrich; T. Reece, Stephen; Şahin, Uğur; S. Tregoning, John

doi:10.1016/j.ymthe.2017.11.017

Public

Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

Published in Molecular Therapy • Dec 6, 2017

Authors:

Annette B. Vogel

Laura Lambert

Ekaterina Kinnear

Abstract

New vaccine platforms are needed to address the time gap between pathogen emergence and vaccine licensure. RNA-based vaccines are an attractive candidate for this role: they are safe, are produced cell free, and can be rapidly generated in response to pathogen emergence. Two RNA vaccine platforms ar...

Subject

RNA

Virology

Hemagglutinin (influenza)

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