Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell-mediated TNFα signaling.

Wang, Weijia; Fujii, Hisaki; Jin Kim, Hye; Hermans, Karin; Usenko, Tatiana; Xie, Stephanie; Luo, Zhi-Juan; Ma, Jennifer; Lo Celso, Cristina; E Dick, John; Schroeder, Timm; Krueger, Joerg; Wall, Donna; Maarten Egeler, R; W Zandstra, Peter

doi:10.1126/scitranslmed.aag3214

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Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell-mediated TNFα signaling.

Shared by NobleBlocks on Dec 20, 2017 • 12:00 AM UTC

Authors:

Weijia Wang

Hisaki Fujii

Hye Jin Kim

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative therapy, but the large number of HSCs required limits its widespread use. Host conditioning and donor cell composition are known to affect HSCT outcomes. However, the specific role that the posttransplantation signaling environm...

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