Triphenylstannyl((arylimino)methyl)benzoates with selective potency that induce G1 and G2/M cell cycle arrest and trigger apoptosis <i>via</i> ROS in human cervical cancer cells

S. Basu Baul, Tushar; Longkumer, Imliwati; Duthie, Andrew; Singh, Priya; Koch, Biplob; Fátima C. Guedes da Silva, M.

doi:10.1039/c7dt04037g

Public

Triphenylstannyl((arylimino)methyl)benzoates with selective potency that induce G1 and G2/M cell cycle arrest and trigger apoptosis via ROS in human cervical cancer cells

Published in Dalton Transactions • Dec 19, 2017

Authors:

Tushar S. Basu Baul

Imliwati Longkumer

Andrew Duthie

Abstract

values revealing high activity. Compared to cisplatin, compounds 1-11 exhibited enhanced cytotoxic efficacy, indicating their potential as potent anticancer agents. Among these, 1 and 5 demonstrated maximum inhibition in HeLa cells, with negligible effect on normal human embryonic kidney (HEK) cells...

Subject

Benzoates

Apoptosis

Cell cycle checkpoint

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