A standardised method for interpreting the association between mutations and phenotypic drug resistance in
                    <i>Mycobacterium tuberculosis</i>

Miotto, Paolo; Tessema, Belay; Tagliani, Elisa; Chindelevitch, Leonid; M. Starks, Angela; Emerson, Claudia; Hanna, Debra; S. Kim, Peter; Liwski, Richard; Zignol, Matteo; Gilpin, Christopher; Niemann, Stefan; M. Denkinger, Claudia; Fleming, Joy; M. Warren, Robin; Crook, Derrick; Posey, James; Gagneux, Sebastien; Hoffner, Sven; Rodrigues, Camilla; Comas, Iñaki; M. Engelthaler, David; Murray, Megan; Alland, David; Rigouts, Leen; Lange, Christoph; Dheda, Keertan; Hasan, Rumina; Devi K. Ranganathan, Uma; McNerney, Ruth; Ezewudo, Matthew; M. Cirillo, Daniela; Schito, Marco; U. Köser, Claudio; C. Rodwell, Timothy

doi:10.1183/13993003.01354-2017

Public

A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis

Shared by NobleBlocks on Dec 1, 2017 • 12:00 AM UTC

Authors:

Paolo Miotto

Belay Tessema

Elisa Tagliani

Abstract

A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis is required to accelerate the development of rapid drug susceptibility testing methods based on genetic sequence. Raw genotype–phenotype correlation data were extracted as part of a comprehensive system...

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