A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis

Miotto, Paolo; Tessema, Belay; Tagliani, Elisa; Chindelevitch, Leonid; M. Starks, Angela; Emerson, Claudia; Hanna, Debra; Kim, Peter; Liwski, Richard; Zignol, Matteo; Gilpin, Christopher; Niemann, Stefan; M. Denkinger, Claudia; Fleming, Joy; M. Warren, Robin; W. Crook, Derrick; E. Posey, James; Gagneux, Sébastien; Hoffner, Sven; Rodrigues, Camilla; Comas, Iñaki; M. Engelthaler, David; Murray, Megan; Alland, David; Rigouts, Leen; Lange, Christoph; Dheda, Keertan; Hasan, Rumina; Devi Ranganathan, Uma; McNerney, Ruth; Ezewudo, Matthew; María Cirillo, Daniela; Schito, Marco; U. Köser, Claudio; C. Rodwell, Timothy

doi:10.1183/13993003.01354-2017

Public

A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis

Published in European Respiratory Journal • Dec 1, 2017

Authors:

Paolo Miotto

Belay Tessema

Elisa Tagliani

Abstract

A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis is required to accelerate the development of rapid drug susceptibility testing methods based on genetic sequence. Raw genotype–phenotype correlation data were extracted as part of a comprehensive system...

Subject

Capreomycin

Moxifloxacin

Medicine

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