TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

Bertrand, Florie; Montfort, Anne; Marcheteau, Elie; Imbert, Caroline; Gilhodes, Julia; Filleron, Thomas; Rochaix, Philippe; Andrieu‐Abadie, Nathalie; Levade, Thierry; Meyer, Nicolás; Colacios, Céline; Ségui, Bruno

doi:10.1038/s41467-017-02358-7

Public

TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

Published in Nature Communications • Dec 18, 2017

Authors:

Florie Bertrand

Anne Montfort

Elie Marcheteau

Abstract

Antibodies against programmed cell death-1 (PD-1) have considerably changed the treatment for melanoma. However, many patients do not display therapeutic response or eventually relapse. Moreover, patients treated with anti-PD-1 develop immune-related adverse events that can be cured with anti-tumor ...

Subject

Blockade

Melanoma

Resistance (ecology)

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