Somatic Activating <i>KRAS</i> Mutations in Arteriovenous Malformations of the Brain

I. Nikolaev, Sergey; Vetiska, Sandra; Bonilla, Ximena; Boudreau, Émilie; Jauhiainen, Suvi; Rezai Jahromi, Behnam; Khyzha, Nadiya; V. DiStefano, Peter; Suutarinen, Santeri; Kiehl, Tim‐Rasmus; Mendes Pereira, Vítor; M. Herman, Alexander; Krings, Timo; Andrade-Barazarte, Hugo; Tung, Takyee; A. Valiante, Taufik; Zadeh, Gelareh; Tymianski, Mike; Rauramaa, Tuomas; Ylä‐Herttuala, Seppo; D. Wythe, Joshua; E. Antonarakis, Stylianos; Frösén, Juhana; E. Fish, Jason; Radovanovic, Ivan

doi:10.1056/nejmoa1709449

Public

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain

Published in New England Journal of Medicine • Jan 17, 2018

Authors:

Sergey I. Nikolaev

Sandra Vetiska

Ximena Bonilla

Abstract

BACKGROUND: Sporadic arteriovenous malformations of the brain, which are morphologically abnormal connections between arteries and veins in the brain vasculature, are a leading cause of hemorrhagic stroke in young adults and children. The genetic cause of this rare focal disorder is unknown. METHODS...

Subject

Arteriovenous malformation

Somatic cell

Stroke (engine)

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