Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma

Sullivan, Keith; Goldmuntz, Ellen; Keyes-Elstein, Lynette; A. McSweeney, Peter; Pinckney, Ashley; Welch, Beverly; D. Mayes, Maureen; A. Nash, Richard; J. Crofford, Leslie; Eggleston, Barry; Castina, Sharon; M. Griffith, Linda; Goldstein, Julia; Wallace, Dennis; Craciunescu, Oana; Khanna, Dinesh; J. Folz, Rodney; Goldin, Jonathan; William St. Clair, E.; R. Seibold, James; Phillips, Kristine; Mineishi, Shin; W. Simms, Robert; K. Ballen, Karen; H. Wener, Mark; E. Georges, George; Heimfeld, Shelly; Hosing, Chitra; J. Forman, Stephen; Kafaja, Suzanne; M. Silver, Richard; Griffing, Leroy; Storek, Jan; LeClercq, Sharon; Brasington, Richard; Ellen Csuka, Mary; Bredeson, Christopher; A. Keever-Taylor, Carolyn; T. Domsic, Robyn; Bashar Kahaleh, M.; A. Medsger, Thomas; E. Furst, Daniel

doi:10.1056/nejmoa1703327

Public

Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma

Published in New England Journal of Medicine • Jan 4, 2018

Authors:

Keith Sullivan

Ellen Goldmuntz

Lynette Keyes-Elstein

Abstract

BACKGROUND: Despite current therapies, diffuse cutaneous systemic sclerosis (scleroderma) often has a devastating outcome. We compared myeloablative CD34+ selected autologous hematopoietic stem-cell transplantation with immunosuppression by means of 12 monthly infusions of cyclophosphamide in patien...

Subject

Scleroderma (fungus)

Medicine

Hematopoietic stem cell transplantation

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