Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Fellows, Rachel; Denizot, Jérémy; Stellato, Claudia; Cuomo, Alessandro; Jain, Payal; Stoyanova, Elena; Balázsi, Szabina; Hajnády, Zoltán; Liebert, Anke; Kazakevych, Juri; Blackburn, Hector; Oliveira Corrêa, Renan; Luís Fachi, José; Takeo Sato, Fábio; R. Ribeiro, Willian; M. Ferreira, Caroline; Perée, Hélène; Spagnuolo, Mariangela; Mattiuz, Raphaël; Matolcsi, Csaba; Guedes, Joana; Clark, Jonathan; Veldhoen, Marc; Bonaldi, Tiziana; Aurélio Ramirez Vinolo, Marco; Varga‐Weisz, Patrick

doi:10.1038/s41467-017-02651-5

Public

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Published in Nature Communications • Jan 3, 2018

Authors:

Rachel Fellows

Jérémy Denizot

Claudia Stellato

Abstract

The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at l...

Subject

Histone

Histone H2A

Histone deacetylase 2

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