miR‐542‐3p prevents ovariectomy‐induced osteoporosis in rats via targeting SFRP1

Zhang, Xiguang; Zhu, Yun; Zhang, Chuanlin; Liu, Jianping; Sun, Tianming; Li, Dan; Qiang, Na; J. Xian, Cory; Wang, Liping; Teng, Zhaowei

doi:10.1002/jcp.26430

Public

miR‐542‐3p prevents ovariectomy‐induced osteoporosis in rats via targeting SFRP1

Published in Journal of Cellular Physiology • Jan 10, 2018

Authors:

Xiguang Zhang

Yun Zhu

Chuanlin Zhang

Abstract

Secreted frizzled-related protein-1 (SFRP1) is a negative regulatory molecule of the WNT signaling pathway and serves as a therapeutic target for bone formation in osteoporosis. In this study, we first established an ovariectomized (OVX) rat model to simulate postmenopausal osteoporosis and found si...

Subject

Osteoporosis

Medicine

Internal medicine

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