Functional variants in the
                    <i>LRRK2</i>
                    gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease

Y. Hui, Ken; Fernandez-Hernandez, Heriberto; Hu, Jianzhong; Schaffner, Adam; Pankratz, Nathan; Hsu, Nai-Yun; Chuang, Ling-Shiang; Carmi, Shai; Villaverde, Nicole; Li, Xianting; Rivas, Manual; P. Levine, Adam; Bao, Xiuliang; R. Labrias, Philippe; Haritunians, Talin; Ruane, Darren; Gettler, Kyle; Chen, Ernie; Li, Dalin; R. Schiff, Elena; Pontikos, Nikolas; Barzilai, Nir; R. Brant, Steven; Bressman, Susan; S. Cheifetz, Adam; N. Clark, Lorraine; J. Daly, Mark; J. Desnick, Robert; H. Duerr, Richard; Katz, Seymour; Lencz, Todd; H. Myers, Richard; Ostrer, Harry; Ozelius, Laurie; Payami, Haydeh; Peter, Yakov; D. Rioux, John; W. Segal, Anthony; K. Scott, William; S. Silverberg, Mark; M. Vance, Jeffery; Ubarretxena-Belandia, Iban; Foroud, Tatiana; Atzmon, Gil; Pe’er, Itsik; Ioannou, Yiannis; P. B. McGovern, Dermot; Yue, Zhenyu; E. Schadt, Eric; H. Cho, Judy; Peter, Inga

doi:10.1126/scitranslmed.aai7795

Public

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease

Shared by NobleBlocks on Jan 10, 2018 • 12:00 AM UTC

Authors:

Ken Y. Hui

Heriberto Fernandez-Hernandez

Jianzhong Hu

Abstract

Crohn’s disease (CD)–associated variants in the LRRK2 gene for risk (N2081D) and for protection (N551K) mediate shared effects in CD and Parkinson’s disease.

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