Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease

Hui, Ken; Fernandez-Hernandez, Heriberto; Hu, Jianzhong; Schaffner, Adam; Pankratz, Nathan; Hsu, Nai-Yun; Chuang, Ling-Shiang; Carmi, Shai; Villaverde, Nicole; Li, Xianting; Rivas, Manual; P. Levine, Adam; Bao, Xiuliang; Ronel Labrias, Philippe; Haritunians, Talin; Ruane, Darren; Gettler, Kyle; Chen, Ernie; Li, Dalin; Schiff, Elena; Pontikos, Nikolas; Barzilai, Nir; R. Brant, Steven; Bressman, Susan; S. Cheifetz, Adam; N. Clark, Lorraine; J. Daly, Mark; J. Desnick, Robert; H. Duerr, Richard; Katz, Seymour; Lencz, Todd; H. Myers, Richard; Ostrer, Harry; J. Ozelius, Laurie; Payami, Haydeh; Peter, Yakov; D. Rioux, John; W. Segal, Anthony; K. Scott, William; S. Silverberg, Mark; M. Vance, Jeffery; Ubarretxena‐Belandia, Iban; Foroud, Tatiana; Atzmon, Gil; Pe’er, Itsik; A. Ioannou, Yiannis; McGovern, Dermot; Yue, Zhenyu; E. Schadt, Eric; H. Cho, Judy; Peter, Inga

doi:10.1126/scitranslmed.aai7795

Public

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease

Published in Science Translational Medicine • Jan 10, 2018

Authors:

Ken Hui

Heriberto Fernandez-Hernandez

Jianzhong Hu

Abstract

alleles in CD and PD provides refined insight into disease mechanisms and may have major implications for the treatment of these two seemingly unrelated diseases.

Subject

LRRK2

Disease

Crohn's disease

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!