Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post‐traumatic osteoarthritis

X. Lin, C.; Shao, Yan; Zeng, Chun; Zhao, Chang; Fang, Hang; Wang, Liping; Pan, Jianying; Liu, Liangliang; Qi, Weizhong; Feng, Xiaofeng; Qiu, Hong; Zhang, Haiyang; Chen, Yuhui; Wang, Hong; Cai, Daozhang; J. Xian, Cory

doi:10.1002/jcp.26460

Public

Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post‐traumatic osteoarthritis

Published in Journal of Cellular Physiology • Jan 11, 2018

Authors:

C. X. Lin

Yan Shao

Chun Zeng

Abstract

PI3K/AKT signaling is essential in regulating pathophysiology of osteoarthritis (OA). However, its potential modulatory role in early OA progression has not been investigated yet. Here, a mouse destabilization OA model in the tibia was used to investigate roles of PI3K/AKT signaling in the early sub...

Subject

PI3K/AKT/mTOR pathway

Protein kinase B

LY294002

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