M1 and M2 Monocytes in Rheumatoid Arthritis: A Contribution of Imbalance of M1/M2 Monocytes to Osteoclastogenesis

Fukui, Shoichi; Iwamoto, Naoki; Takatani, Ayuko; Igawa, Takashi; Shimizu, Toshimasa; Umeda, Masataka; Nishino, Ayako; Horai, Yoshiro; Hirai, Yasuko; Koga, Tomohiro; Kawashiri, Shin‐ya; Tamai, Mami; Ichinose, Kunihiro; Nakamura, Hideki; Origuchi, Tomoki; Masuyama, Ritsuko; Kosai, Kosuke; Yanagihara, Katsunori; Kawakami, Atsushi

doi:10.3389/fimmu.2017.01958

Public

M1 and M2 Monocytes in Rheumatoid Arthritis: A Contribution of Imbalance of M1/M2 Monocytes to Osteoclastogenesis

Published in Frontiers in Immunology • Jan 8, 2018

Authors:

Shoichi Fukui

Naoki Iwamoto

Ayuko Takatani

Abstract

Objectives: We investigated the relationships among M1 monocytes, M2 monocytes, osteoclast differentiation ability and clinical characteristics in patients with rheumatoid arthritis (RA). Methods: Peripheral blood mononuclear cells (PBMCs) were isolated from RA patients and healthy donors, and we th...

Subject

CD14

Medicine

Peripheral blood mononuclear cell

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