Ulinastatin Protects Against LPS-Induced Acute Lung Injury By Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators

Cao, Chao; Yin, Chengfen; Shou, Songtao; Wang, Jun; Yu, Lechang; Li, Xuening; Chai, Yanfen

doi:10.1097/shk.0000000000001104

Public

Ulinastatin Protects Against LPS-Induced Acute Lung Injury By Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators

Published in Shock • Jan 12, 2018

Authors:

Chao Cao

Chengfen Yin

Songtao Shou

Abstract

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome, remain the leading causes of morbidity and mortality in intensive care units. Ulinastatin (UTI), a serine protease inhibitor, possesses anti-inflammatory properties and has been suggested to modulate lipopolysaccharide...

Subject

TLR4

Ulinastatin

Proinflammatory cytokine

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