Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts

M. Seibert, Tyler; Chieh Fan, Chun; Wang, Yunpeng; Zuber, Verena; Karunamuni, Roshan; Kellogg Parsons, J.; A. Eeles, Rosalind; F. Easton, Douglas; Kote‐Jarai, Zsofia; Amin Al Olama, Ali; Benlloch Garcia, Sara; Muir, Kenneth; Grönberg, Henrik; Wiklund, Fredrik; Aly, Markus; Schleutker, Johanna; Sipeky, Csilla; L.J. Tammela, Teuvo; G. Nordestgaard, Børge; F. Nielsen, Sune; Weischer, Maren; Bisbjerg, Rasmus; Andreas Røder, Martin; Iversen, Peter; J. Key, Timothy; C. Travis, Ruth; E. Neal, David; Donovan, Jenny; C. Hamdy, Freddie; D.P. Pharoah, Paul; Pashayan, Nora; Khaw, Kay‐Tee; Maier, Christiane; Vogel, Walther; Luedeke, Manuel; Herkommer, Kathleen; S. Kibel, Adam; Cybulski, Cezary; Wokołorczyk, Dominika; Kluźniak, Wojciech; Cannon‐Albright, Lisa; Brenner, Hermann; Ćuk, Katarina; Saum, Kai-Uwe; Y. Park, Jong; A. Sellers, Thomas; Slavov, Chavdar; Kaneva, Radka; Mitev, Vanio; Batra, Jyotsna; A. Clements, Judith; B. Spurdle, Amanda; R. Teixeira, Manuel; Paulo, Paula; Maia, Sofia; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej; S. Karow, David; G. Mills, Ian; A. Andreassen, Ole; M. Dale, Anders

doi:10.1136/bmj.j5757

Public

Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts

Published in BMJ • Jan 10, 2018

Authors:

Tyler M. Seibert

Chun Chieh Fan

Yunpeng Wang

Abstract

OBJECTIVES: To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age. DESIGN: Analysis of genotype, PCa status, and age to select single nucleotide polymorphisms (SNPs) associated with diagnosis. These ...

Subject

Prostate cancer

Scale (ratio)

Hazard

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!