Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

Fang, Tian; Lv, Hongwei; Lv, Guishuai; Li, Ting; Wang, Changzheng; Han, Qin; Yu, Le‐Xing; Su, Bo; Guo, Linna; Huang, Shanna; Cao, Dan; Tang, Liang; Tang, Shanhua; Wu, Mengchao; Yang, Wen; Wang, Hongyang

doi:10.1038/s41467-017-02583-0

Public

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

Published in Nature Communications • Jan 9, 2018

Authors:

Tian Fang

Hongwei Lv

Guishuai Lv

Abstract

The communication between tumor-derived elements and stroma in the metastatic niche has a critical role in facilitating cancer metastasis. Yet, the mechanisms tumor cells use to control metastatic niche formation are not fully understood. Here we report that in the lung metastatic niche, high-metast...

Subject

Cancer research

Metastasis

Cancer

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