Identification of genes required for <i>Mycobacterium abscessus</i> growth in vivo with a prominent role of the ESX-4 locus

Laencina, Laura; Dubois, Violaine; Le Moigne, Vincent; Viljoen, Albertus; Majlessi, Laleh; R. Pritchard, Justin; Bernut, Audrey; Piel, Laura; Roux, Anne-Laure; Gaillard, Jean-Louis; Lombard, Bérengère; Loew, Damarys; J. Rubin, Eric; Brosch, Roland; Kremer, Laurent; Herrmann, Jean‐Louis; Girard‐Misguich, Fabienne

doi:10.1073/pnas.1713195115

Public

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus

Published in Proceedings of the National Academy of Sciences • Jan 17, 2018

Authors:

Laura Laencina

Violaine Dubois

Vincent Le Moigne

Abstract

Significance The coevolution of mycobacteria and amoebae seems to have contributed to shaping the virulence of nontuberculous mycobacteria in macrophages. We identified a pool of genes essential for the intracellular survival of Mycobacterium abscessus inside amoebae and macrophages and discovered a...

Subject

Mycobacterium abscessus

Virulence

Microbiology

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