Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis

Coll, Francesc; Phelan, Jody; Hill-Cawthorne, Grant; Nair, Mridul; Mallard, Kim; Ali, Shahjahan; M. Abdallah, Abdallah; Alghamdi, Saad; Alsomali, Mona; O. Ahmed, Abdallah; Portelli, Stephanie; Oppong, Yaa; Alves, Adriana; Barbosa, Theolis; Campino, Susana; Caws, Maxine; Chatterjee, Anirvan; C. Crampin, Amelia; Dheda, Keertan; Furnham, Nicholas; R. Glynn, Judith; Grandjean, Louis; Minh Ha, Dang; Hasan, Rumina; Hasan, Zahra; L. Hibberd, Martin; Joloba, Moses; C. Jones‐López, Edward; Matsumoto, Tomoshige; Miranda, Anabela; Moore, David; Mocillo, Nora; Panaiotov, Stefan; Parkhill, Julian; Penha‐Gonçalves, Carlos; Perdigão, João; Portugal, Isabel; Rchiad, Zineb; Robledo, Jaime; Sheen, Patricia; Talaat Shesha, Nashwa; A Sirgel, F; Sola, Christophe; Oliveira Sousa, Erivelton; M. Streicher, Elizabeth; D. van Helden, Paul; Viveiros, Miguel; M. Warren, Robin; McNerney, Ruth; Pain, Arnab; G. Clark, Taane

doi:10.1038/s41588-017-0029-0

Public

Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis

Published in Nature Genetics • Jan 16, 2018

Authors:

Francesc Coll

Jody Phelan

Grant Hill-Cawthorne

Abstract

To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mixed-regression framework was followed by a phylogenetics...

Subject

Biology

Mycobacterium tuberculosis

Drug

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