Synthesis of Quinazolines via an Iron-Catalyzed Oxidative Amination of N-H Ketimines.

CY, Chen; F, He; G, Tang; H, Yuan; N, Li; J, Wang; R, Faessler

doi:10.1021/acs.joc.7b02943

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Synthesis of Quinazolines via an Iron-Catalyzed Oxidative Amination of N-H Ketimines.

Shared by NobleBlocks on Jan 29, 2018 • 12:00 AM UTC

Authors:

Chen CY

He F

Tang G

Abstract

An efficient synthesis of quinazolines based on an iron-catalyzed C(sp3)-H oxidation and intramolecular C-N bond formation using tert-BuOOH as the terminal oxidant is described. The reaction of readily available 2-alkylamino benzonitriles with various organometallic reagents led to 2-alkylamino N-H ...

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