Synthesis of Quinazolines via an Iron-Catalyzed Oxidative Amination of N–H Ketimines

Chen, Cheng‐yi; He, Fengxian; Tang, Guangrong; Yuan, Huiqing; Li, Ning; Wang, Jinmin; Faessler, Roger

doi:10.1021/acs.joc.7b02943

Public

Synthesis of Quinazolines via an Iron-Catalyzed Oxidative Amination of N–H Ketimines

Published in The Journal of Organic Chemistry • Jan 17, 2018

Authors:

Cheng‐yi Chen

Fengxian He

Guangrong Tang

Abstract

An efficient synthesis of quinazolines based on an iron-catalyzed C(sp 3 )-H oxidation and intramolecular C–N bond formation using tert -BuOOH as the terminal oxidant is described. The reaction of readily available 2-alkylamino benzonitriles with various organometallic reagents led to 2-alkylamino N...

Subject

Chemistry

Intramolecular force

Aromatization

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