Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

N. Beaumont, Robin; M. Warrington, Nicole; Cavadino, Alana; Tyrrell, Jessica; Nodzenski, Michael; Horikoshi, Momoko; Geller, Frank; Myhre, Ronny; C. Richmond, Rebecca; Paternoster, Lavinia; P. Bradfield, Jonathan; Kreiner‐Møller, Eskil; Huikari, Ville; Metrustry, Sarah; L. Lunetta, Kathryn; N. Painter, Jodie; Hottenga, Jouke‐Jan; Allard, Catherine; J. Barton, Sheila; Espinosa, Ana; Marsh, Julie; Potter, Catherine; Zhang, Ge; Ang, Wei; J. Berry, Diane; Bouchard, Luigi; Das, Shikta; Håkonarson, Håkon; Heikkinen, Jani; Helgeland, Øyvind; Hocher, Berthold; Hofman, Albert; Inskip, Hazel; E. Jones, Samuel; Kogevinas, Manolis; A. Lind, Penelope; Marullo, Letizia; E. Medland, Sarah; Murray, Anna; C. Murray, Jeffrey; R. Njølstad, Pål; A. Nøhr, Ellen; Reichetzeder, Christoph; M. Ring, Susan; S. Ruth, Katherine; Santa‐Marina, Loreto; Scholtens, Denise; Sebért, Sylvain; Sengpiel, Verena; A. Tuke, Marcus; Vaudel, Marc; N. Weedon, Michael; Willemsen, Gonneke; R. Wood, Andrew; Yaghootkar, Hanieh; J. Muglia, Louis; Bartels, Meike; L. Relton, Caroline; E. Pennell, Craig; Chatzi, Leda; Estivill, Xavier; W. Holloway, John; I. Boomsma, Dorret; W. Montgomery, Grant; M. Murabito, Joanne; D. Spector, Tim; Power, Christine; Järvelin, Marjo‐Riitta; Bisgaard, Hans; F.A. Grant, Struan; I. A. Sørensen, Thorkild; W.V. Jaddoe, Vincent; Jacobsson, Bo; Melbye, Mads; I. McCarthy, Mark; T. Hattersley, Andrew; Geoffrey Hayes, M.; M. Frayling, Timothy; Hivert, Marie‐France; F. Felix, Janine; Hyppönen, Elina; L. Lowe, William; M. Evans, David; A. Lawlor, Debbie; Feenstra, Bjarke; M. Freathy, Rachel

doi:10.1093/hmg/ddx429

Public

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Published in Human Molecular Genetics • Jan 2, 2018

Authors:

Robin N. Beaumont

Nicole M. Warrington

Alana Cavadino

Abstract

Genome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants...

Subject

Biology

Offspring

Genome-wide association study

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