Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

Espino Guarch, Meritxell; Font-Llitjós, Mariona; Murillo‐Cuesta, Silvia; Errasti‐Murugarren, Ekaitz; M. Celaya, Adelaida; Girotto, Giorgia; Vuckovic, Dragana; Mezzavilla, Massimo; Vilches, Clara; Bodoy, Susanna; Sahún, Ignasi; González, Laura; Prat, Esther; Zorzano, António; Dierssen, Mara; Varela‐Nieto, Isabel; Gasparini, Paolo; Palacı́n, Manuel; Nunes, Virginia

doi:10.7554/elife.31511

Public

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

Published in eLife • Jan 22, 2018

Authors:

Meritxell Espino Guarch

Mariona Font-Llitjós

Silvia Murillo‐Cuesta

Abstract

Age-related hearing loss (ARHL) is the most common sensory deficit in the elderly. The disease has a multifactorial etiology with both environmental and genetic factors involved being largely unknown. SLC7A8/SLC3A2 heterodimer is a neutral amino acid exchanger. Here, we demonstrated that SLC7A8 is e...

Subject

Hearing loss

Genetics

Audiology

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