Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi

, we show that two NRPSs, ApmA and ApmB, are sufficient for the synthesis of an amino acid ester, asperphenamate. Using the heterologous expression system, we identified that ApmA, with a reductase domain, rarely generates dipeptidyl alcohol. In contrast, ApmB was determined to not only catalyse int... View More