Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis

Gu, Junlian; Wang, Shudong; Guo, Hua; Tan, Yi; Liang, Yaqin; Feng, Anyun; Liu, Qiuju; Damodaran, Chendil; Zhang, Zhiguo; B. Keller, Bradley; Zhang, Chi; Cai, Lu

doi:10.1038/s41419-017-0093-5

Public

Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis

Published in Cell Death and Disease • Jan 23, 2018

Authors:

Junlian Gu

Shudong Wang

Hua Guo

Abstract

Elevated tumor suppressor p53 expression has been associated with heart diseases, including the diabetic heart. However, its precise role in the pathogenesis of diabetic cardiomyopathy (DCM) remains unclear. We hypothesized that the development of DCM is attributed to up-regulated p53-mediated both ...

Subject

Diabetic cardiomyopathy

Senescence

Diabetes mellitus

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!