Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma

Xie, Jian-Jun; Jiang, Yan-Yi; Jiang, Yuan; Li, Chunquan; Chee Lim, Mei; An, Ömer; Mayakonda, Anand; Ding, Ling‐Wen; Long, Lin; Sun, Chun; Lin, Le-Hang; Chen, Li; Wu, Jian-Yi; Wu, Zhi-Yong; Cao, Qi; Fang, Wang‐Kai; Yang, Wei; J. Soukiasian, Harmik; J. Meltzer, Stephen; Yang, Henry; J. Fullwood, Melissa; Xu, Li‐Yan; Li, En‐Min; Lin, De‐Chen; Phillip Koeffler, H.

doi:10.1053/j.gastro.2018.02.018

Public

Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma

Published in Gastroenterology • Feb 15, 2018

Authors:

Jian-Jun Xie

Yan-Yi Jiang

Yuan Jiang

Abstract

Background & AimsLong non-coding RNAs (lncRNAs) are expressed in tissue-specific pattern, but it is not clear how these are regulated. We aimed to identify squamous cell carcinoma (SCC)-specific lncRNAs and investigate mechanisms that control their expression and function.MethodsWe studied expressio...

Subject

Chromatin immunoprecipitation

Gene knockdown

Biology

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