Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

Chen, Shuo; Z. Weitemier, Adam; Zeng, Xiao; He, Linmeng; Wang, Xiyu; Tao, Yanqiu; Huang, Arthur; Hashimotodani, Yuki; Kano, Masanobu; Iwasaki, Hirohide; Kumar Parajuli, Laxmi; Okabe, Shigeo; Boon Loong Teh, Daniel; H. All, Angelo; Tsutsui‐Kimura, Iku; F. Tanaka, Kenji; Liu, Xiaogang; J. McHugh, Thomas

doi:10.1126/science.aaq1144

Public

Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

Published in Science • Feb 9, 2018

Authors:

Shuo Chen

Adam Z. Weitemier

Xiao Zeng

Abstract

Optogenetics has revolutionized the experimental interrogation of neural circuits and holds promise for the treatment of neurological disorders. It is limited, however, because visible light cannot penetrate deep inside brain tissue. Upconversion nanoparticles (UCNPs) absorb tissue-penetrating near-...

Subject

Optogenetics

Neuroscience

Deep brain stimulation

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