Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors

J. Luke, Jason; M. Lemons, Jeffrey; Karrison, Theodore; P. Pitroda, Sean; Melotek, J.M.; Zha, Yuanyuan; Al‐Hallaq, Hania; Arina, Ainhoa; N. Khodarev, Nikolai; Janisch, Linda; J. Chang, Paul; D. Patel, Jyoti; F. Fleming, Gini; W. Moroney, John; Sharma, Manish; White, Julia; J. Ratain, Mark; F. Gajewski, Thomas; R. Weichselbaum, Ralph; J. Chmura, Steven

doi:10.1200/jco.2017.76.2229

Public

Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors

Published in Journal of Clinical Oncology • Feb 13, 2018

Authors:

Jason J. Luke

Jeffrey M. Lemons

Theodore Karrison

Abstract

Purpose Stereotactic body radiotherapy (SBRT) may stimulate innate and adaptive immunity to augment immunotherapy response. Multisite SBRT is an emerging paradigm for treating metastatic disease. Anti-PD-1-treatment outcomes may be improved with lower disease burden. In this context, we conducted a ...

Subject

Medicine

Pembrolizumab

Context (archaeology)

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