H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming.

X, Liu; Y, Wang; Y, Gao; J, Su; J, Zhang; X, Xing; C, Zhou; K, Yao; Q, An; Y, Zhang

doi:10.1242/dev.158261

Public

H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming.

Shared by NobleBlocks on Feb 16, 2018 • 12:00 AM UTC

Authors:

Liu X

Wang Y

Gao Y

Abstract

Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear transfer (SCNT) embryos during embryonic genome activation (EGA). Bovine eight-cell SCNT embryos exhibit global hypermethylation of histone H3 lysine 9 tri- and di-methylation (H3K9me3/2), but the intrin...

Subject

Embryonic development

Scnt

Embryonic Genome Activation

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