NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

P. Böttcher, Jan; Bonavita, Eduardo; Chakravarty, Probir; Blees, H.; Cabeza-Cabrerizo, Mar; Sammicheli, Stefano; C. Rogers, Neil; Sahai, Erik; Zelenay, Santiago; Reis e Sousa, Caetano

doi:10.1016/j.cell.2018.01.004

Public

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

Published in Cell • Feb 1, 2018

Authors:

Jan P. Böttcher

Eduardo Bonavita

Probir Chakravarty

Abstract

Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their abundance within tumors is associated with immune-mediated rejection and the success of immunotherapy. Here, we show that cDC1 accumulation in mouse tumors often depends on natural killer (NK) cells that produc...

Subject

Biology

Immune system

Tumor microenvironment

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