Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Balmus, Gabriel; Larrieu, Delphine; C. Barros, Ana; Collins, Casey; Abrudan, Monica; Demir, Mukerrem; J. Geisler, Nicola; J. Lelliott, Christopher; K. White, Jacqueline; A. Karp, Natasha; Atkinson, James; Kirton, Andrea; Jacobsen, Matt; Clift, Dean; Rodriguez, Raphaël; Mouse Genetics Project, Sanger; Shannon, Carl; Sanderson, Mark; Gates, Amy; Dench, Joshua; E. Vancollie, Valerie; McCarthy, Catherine; Pearson, Selina; L. Cambridge, Emma; Isherwood, Christopher; Wilson, Heather; Grau, Evelyn; Galli, Antonella; Hooks, Yvette; Tudor, Catherine; L. Green, Angela; Kussy, Fiona; Tuck, Elizabeth; Siragher, Emma; S. B. McLaren, Robbie; Świątkowska, Agnieszka; Caetano, Susana; Mazzeo, Cecilia; Dabrowska, Monika; A. Maguire, Simon; Lafont, David; F. E. Anthony, Lauren; T. Sumowski, Maksymilian; Bussell, James; Sinclair, Caroline; Brown, Ellen; Doe, Brendan; Wardle‐Jones, Hannah; Griggs, Nicola; Woods, Mike; Kundi, Helen; McConnell, George; Doran, Joanne; Griffiths, Mark; Kipp, Christian; Holroyd, S.; J. Gannon, David; Alcántara, Rafael; Ramírez‐Solis, Ramiro; Bottomley, Joanna; Ingle, Catherine; Ross, Victoria; M. Barrett, Daniel; Sethi, Debarati; Gleeson, Diane; Burvill, Jonathan; Platte, Radka; Ryder, Edward; Sins, Elodie; Miklejewska, Evelina; Von Schiller, Dominique; Duddy, Graham; Urbanová, Jana; Boroviak, Katharina; Imran, Maria; Kamu Reddy, Shalini; J. Adams, David; P. Jackson, Stephen

doi:10.1038/s41467-018-03770-3

Public

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Published in Nature Communications • Apr 23, 2018

Authors:

Gabriel Balmus

Delphine Larrieu

Ana C. Barros

Abstract

Abstract Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, but devastating genetic disease characterized by segmental premature aging, with cardiovascular disease being the main cause of death. Cells from HGPS patients accumulate progerin, a permanently farnesylated, toxic form of Lamin A, disr...

Subject

Biology

Cell biology

Medicine

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