BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

McArthur, Kate; Whitehead, Lachlan; M. Heddleston, John; Li, Lucy; Scott Padman, Benjamin; Oorschot, Viola; D. Geoghegan, Niall; Chappaz, Stéphane; Davidson, Sophia; San Chin, Hui; M. Lane, Rachael; Dramićanin, Marija; L. Saunders, Tahnee; Sugiana, Canny; Lessene, Romina; D. Osellame, Laura; Chew, Teng-Leong; Dewson, Grant; Lazarou, Michael; Ramm, Georg; Lessène, Guillaume; T. Ryan, Michael; L. Rogers, Kelly; F. van Delft, Mark; T. Kile, Benjamin

doi:10.1126/science.aao6047

Public

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Published in Science • Feb 22, 2018

Authors:

Kate McArthur

Lachlan Whitehead

John M. Heddleston

Abstract

Mitochondrial apoptosis is mediated by BAK and BAX, two proteins that induce mitochondrial outer membrane permeabilization, leading to cytochrome c release and activation of apoptotic caspases. In the absence of active caspases, mitochondrial DNA (mtDNA) triggers the innate immune cGAS/STING pathway...

Subject

Mitochondrial DNA

Apoptosis

Macropore

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