BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

McArthur, Kate; W. Whitehead, Lachlan; M. Heddleston, John; Li, Lucy; S. Padman, Benjamin; Oorschot, Viola; D. Geoghegan, Niall; Chappaz, Stephane; Davidson, Sophia; San Chin, Hui; M. Lane, Rachael; Dramicanin, Marija; L. Saunders, Tahnee; Sugiana, Canny; Lessene, Romina; D. Osellame, Laura; Chew, Teng-Leong; Dewson, Grant; Lazarou, Michael; Ramm, Georg; Lessene, Guillaume; T. Ryan, Michael; L. Rogers, Kelly; F. van Delft, Mark; T. Kile, Benjamin

doi:10.1126/science.aao6047

Public

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Shared by NobleBlocks on Feb 23, 2018 • 12:00 AM UTC

Authors:

Kate McArthur

Lachlan W. Whitehead

John M. Heddleston

Abstract

The great escape Mitochondrial DNA (mtDNA) is a potent damage-associated molecular pattern that, if it reaches the cytoplasm or extracellular milieu, triggers innate immune pathways. mtDNA signaling has been implicated in a wide range of diseases; however, the mechanisms of mtDNA release are unclear...

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