Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

Wu, Yang; Zeng, Jian; Zhang, Futao; Zhu, Zhihong; Qi, Ting; Zheng, Zhili; R. Lloyd‐Jones, Luke; E. Marioni, Riccardo; G. Martin, Nicholas; W. Montgomery, Grant; J. Deary, Ian; R. Wray, Naomi; M. Visscher, Peter; F. McRae, Allan; Yang, Jian

doi:10.1038/s41467-018-03371-0

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Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

Published in Nature Communications • Feb 26, 2018

Authors:

Yang Wu

Jian Zeng

Futao Zhang

Abstract

The identification of genes and regulatory elements underlying the associations discovered by GWAS is essential to understanding the aetiology of complex traits (including diseases). Here, we demonstrate an analytical paradigm of prioritizing genes and regulatory elements at GWAS loci for follow-up ...

Subject

dNaM

Biology

Genome-wide association study

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