Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain

Navarro, Gemma; Cordomí, Arnau; Brugarolas, Marc; Moreno, Estefanía; Aguinaga, David; Pérez‐Benito, Laura; Ferré, Sergi; Cortés, Antoni; Casadó, Vicent; Mallol, Josefa; I. Canela, Enric; Lluı́s, Carme; Pardo, Leonardo; J. McCormick, Peter; Franco, Rafael

doi:10.1186/s12915-018-0491-x

Public

Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain

Published in BMC Biology • Feb 23, 2018

Authors:

Gemma Navarro

Arnau Cordomí

Marc Brugarolas

Abstract

G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A 1 R or A 2A R) can form A 1 R-A 2A R heteromers (A 1 -A 2A Het), and their activation leads to canonical G-protein-dependent (ade...

Subject

G protein-coupled receptor

Biology

Adenosine receptor

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