Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart

Yang, Hong; Feng, Anyun; Lin, Sundong; Yu, Lechu; Lin, Xiufei; Yan, Xiaoqing; Lu, Xuemian; Zhang, Chi

doi:10.1038/s41419-018-0307-5

Public

Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart

Published in Cell Death and Disease • Feb 14, 2018

Authors:

Hong Yang

Anyun Feng

Sundong Lin

Abstract

Our previous studies showed that both exogenous and endogenous FGF21 inhibited cardiac apoptosis at the early stage of type 1 diabetes. Whether FGF21 induces preventive effect on type 2 diabetes-induced cardiomyopathy was investigated in the present study. High-fat-diet/streptozotocin-induced type 2...

Subject

FGF21

Diabetic cardiomyopathy

AMPK

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